Few hematologic malignancies arise primarily in the spleen; most conditions occurring at this site represent secondary involvement by diseases originating elsewhere in the body. The role of the pathologist in most cases is to confirm the known or suspected diagnosis…
Non-Neoplastic Diseases Involving the Splenic White Pulp Reactive Follicular Hyperplasia With Germinal Center Formation Clinical Features Occurs at any age; more common in children and younger adults Caused by a variety of both acute and chronic immunologic stimuli (e.g., bacterial…
Normal Lymph Node Histopathology A lymph node contains a cortex, a paracortex, a medulla, sinuses, a hilum, and a fibrous capsule The cortex is a B-cell area, which contains primary (nonstimulated) lymphoid follicles composed of small mature lymphocytes and secondary…