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Systems and Network Pharmacology Strategies for Pancreatic Ductal Adenocarcinoma Therapy : A Resource Review

Introduction According to the World Cancer Research Fund (WCRF) there were 279,000 cases of pancreatic cancer diagnosed worldwide in 2008 ( ). The estimated five-year prevalence of people living with pancreatic cancer is projected at 3.5% per 100,000 and…

Prioritizing Diagnostic, Prognostic, and Therapeutic MicroRNAs in Pancreatic Cancer: Systems and Network Biology Approaches

An Introduction and Brief Overview of MicroRNAs MicroRNAs (miRNAs) are short noncoding RNAs 22 nucleotides in length that carry out complex regulatory functions through post-transcriptional targeting and modification. Initially, these miRNAs were discovered through analyses of Caenorhabditis elegans development, in…

Systems Biology of Pancreatic Cancer Stem Cells

Acknowledgment We acknowledge Dr Fazlul Sarkar for providing the necessary reagents (CSCs) to conduct the studies described in this chapter. Introduction Pancreatic cancer (PC) kills ∼300,000 individuals worldwide, and each year in the United States there are an estimated 43,920…