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1 Are some disorders of pigmentation markers for systemic disease? Yes. Examples include the following: Generalized depigmentation: Albinism. Generalized hyperpigmentation: Addison's disease. Ash-leaf hypopigmented macules: Tuberous sclerosis. Axillary and inguinal freckles: Neurofibromatosis. Lentigines: Peutz-Jeghers syndrome. 2 How do you diagnose…