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Acknowledgments This work is supported in part by the Instituto de Salud Carlos III FEDER (Fondo Europeo de Desarrollo Regional; DTS16/00160; PI14/00857, PI16/01123; PI17/01059; PI17/01106); the Agencia Estatal de Investigación RYC2018-024346-I, Generalitat Valenciana grants (APOSTD/2017 and APOSTD/2018) and projects (GVA/2018/267);…