The Skin: More Than a Mechanical Barrier More than a century and a half ago, the noted pathologist Rudolph Virchow described the skin as a mere protective covering for more delicate and functionally sophisticated internal viscera. Subsequently, the skin was…
Introduction Connective tissue tumors presenting primarily in the skin are relatively common. Because the majority of such lesions are benign and clinically nondistinctive they are sometimes neglected by clinicians. However, histologically they constitute a complex group of tumors showing various…
Melanoma Clinical features Over the last several decades, the conspicuous increasing incidence of this malignant neoplasm has made this disease more prominent, linked to some rise in morbidity and mortality. While roughly half of the major cancers in the United…
Specimen fixation, grossing/put-through, processing, embedding and sectioning The aim of fixation is to maintain clear and consistent lesional features and to preserve tissue in an optimal state suitable for a range of staining and ancillary histopathological techniques. Most fixation methods…
Key Points Sarcomas of the skin comprise numerous rare entities that commonly present as nodules or plaques. Cutaneous sarcomas exhibit differentiation toward a variety of mesenchymal lineages. Dermatofibrosarcoma protuberans, atypical fibroxanthoma, and cutaneous leiomyosarcoma are the most common types. Diagnosis…