Local anesthetics are nondiscriminating compounds that have a low affinity for all seven isoforms of voltage-gated sodium channels in tissues (e.g., myocardium, skeletal muscle, brain, spinal cord, and nerves). There is minimal variation in local anesthetic affinity among these isoforms,…
Local anesthetics are nondiscriminating compounds that have a low affinity for all seven isoforms of voltage-gated sodium channels in tissues (e.g., myocardium, skeletal muscle, brain, spinal cord, and nerves). There is minimal variation in local anesthetic affinity among these isoforms,…
THE POPULATION IN THE DEVELOPING WORLD CONTINUES TO GROW while world demographics trend toward an aging population in an urbanized, developed world. Children, many orphaned by the ravages of war, human immunodeficiency virus (HIV) infection, and famine, constitute more than…