Surgery of the Left Heart Valve Infective Endocarditis

Step 1

Pathogenesis, Pathology, and Microbiology of Left-Sided Infective Endocarditis

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  Infective endocarditis (IE) is the most severe and devastating complication of heart valve disease, whether it is native valve endocarditis (NVE), prosthetic valve endocarditis (PVE), or infection on another cardiac device. Despite advances in surgical technique, operations for IE remain associated with the highest mortality of any valve disease.

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  IE patients require a multispecialty team approach, which includes an infectious disease specialist, cardiologist, and cardiac surgeon, with input from other specialties, such as neurology and nephrology, when needed. This is because the clinical scenarios presented by patients with IE are often very complex and require prompt diagnosis for the early institution of antibiotic treatment and decision making related to complications, including the risk of embolism and need for and timing of high-risk surgery.

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  The microbiology of IE depends on whether the valve is native or prosthetic and whether the infection is community or hospital acquired. Staphylococci, streptococci, and enterococci are responsible for about 85% of all cases of IE.

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  The infecting organisms produce and release virulence factors, including toxins, and enzymes. The enzymes produced are organism-specific regarding tissue specificity and efficiency. The severity of invasion and destruction, involvement of the valve annulus and beyond, occurs in stages—cellulitis, abscess, abscess cavity, and finally pseudoaneurysm—and are a function of virulence and time, with Staphylococcus aureus being the most aggressive and destructive.

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  The capacity of biofilm production, which protects bacteria from host immune defenses and impedes antimicrobial efficacy, thus significantly reducing the ability of medical therapy alone to eradicate the infection, is a hallmark of microorganisms commonly causing IE.

Step 2

Diagnosis of Infective Endocarditis

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  A high index of suspicion and low threshold to perform the examination and studies necessary to exclude IE are essential to diagnosis and early treatment. The diagnosis of IE is based on clinical symptoms, physical findings, microbiology results, echocardiograms, and other results. Echocardiography and blood cultures are the cornerstones of diagnosing IE. Whenever possible, blood cultures should be obtained before starting antibiotics.

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  Transthoracic echocardiography (TTE) must be supplemented with transesophageal echocardiography (TEE) in most cases of suspected PVE. TEE is more sensitive than TTE and remains the present gold standard diagnostic modality for documenting IE. The role and added value of cardiac computed tomography (CT), magnetic resonance imaging (MRI), and other complementary imaging technologies are still unclear.

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  Duke criteria or modified Duke criteria are used to confirm the certainty of the diagnosis. However, clinical judgment is very important on an individual basis, such as PVE and negative blood cultures, and so on ( Table 15.1 ).

  Table 15.1

  Modified duke criteria for the diagnosis of infective endocarditis

  Used with permission from Li JS, Sexton DJ, Mick N, et al: Proposed modifications to the Duke Criteria for the diagnosis of infective endocarditis. Clin Infect Dis 2000; 30:633.

  MAJOR CRITERIA
  Blood culture positive for infective endocarditis
  Typical microorganisms consistent with infective endocarditis from two separate blood cultures: Streptococcus viridans, S. bovis HACEK group, S. aureus, or community-acquired enterococci, in the absence of a primary focus, or Microorganisms consistent with infective endocarditis from a persistently positive blood culture, defined as follows: At least two positive cultures of blood drawn >12 hours apart, or All of three or a majority of >four separate cultures of blood (with the first and last samples drawn at least 1 hour apart) Single positive blood culture for Coxiella burnetii or phase I IgG antibody titer to C. burnetii > 1:800 Evidence of endocardial involvement: Echocardiogram positive for infective endocarditis: TEE recommended in patients with prosthetic valves, rated at least as “possible endocarditis” by clinical criteria, or complicated endocarditis, such as endocarditis with paravalvular abscess; TTE as the first test in other patients as follows: Oscillating intracardiac mass on valve or supporting structures, in the path of regurgitant jets, or on implanted material in the absence of an alternative anatomic explanation; Abscess: New partial dehiscence of prosthetic valve New valvular regurgitation (worsening or changing of preexisting murmur not sufficient)
  MINOR CRITERIA
  Predisposition, predisposing heart condition, or injection drug use Fever Vascular phenomena: major arterial emboli, septic pulmonary infarcts, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhages, and Janeway lesions Immunologic phenomena: glomerulonephritis, Osler nodes, Roth spots, and rheumatoid factor Microbiologic evidence: positive blood culture but does not meet a major criterion as noted above, or serologic evidence of active infection with an organism consistent with infective endocarditis Echocardiographic minor criteria eliminated

  Definite endocarditis, two major criteria, or one major + three minor criteria, or five minor criteria; HACEK group , Haemophilus, Actinobacillus, Cardiobacterium, Eikenella, and Kingella; IE , infective endocarditis; possible endocarditis, one major + one minor, or three minor criteria; TEE , transesophageal echocardiography; TTE m transthoracic echocardiography.

Step 3

Special Considerations Related to Surgery for Infective Endocarditis

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  Surgical treatment should be considered for patients with signs of heart failure, severe valve dysfunction, PVE, invasion with paravalvular abscess or cardiac fistulas, recurrent systemic embolization, large mobile vegetations, and persistent sepsis despite adequate antibiotic therapy for more than 5 to 7 days. Most patients with PVE will require surgery. See the next section for indications for surgery.

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  Early surgery is recommended. Once a surgical indication is present, surgery should not be delayed. Early surgery is defined as being carried out “during initial hospitalization independently of completion of a full therapeutic course of antibiotics.”

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  All patients with IE who require surgery but have neurologic symptoms should have a neurologic evaluation and brain imaging by CT or MRI before the planned operation. Imaging may need to be repeated in case of new or worsening symptoms.

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  In general, surgery should be delayed for 1 to 2 weeks for patients with nonhemorrhagic strokes and 3 to 4 weeks for patients with hemorrhagic strokes. For those with nonhemorrhagic embolic strokes, earlier intervention may be justified. The risk of the worsening of stroke symptoms must be weighed against the indications for surgery and risk of additional emboli during the waiting period, in consultation with a neurologist.

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  The need for preoperative coronary angiography should be guided by normal criteria. CT angiography is an alternative to assess coronary anatomy in patients with large aortic valve vegetations.

Step 4

Indications for Surgery in Left-Sided Infective Endocarditis