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Posttransplant Lymphoproliferative Disorders and Immunodeficiency


General Overview and Incidence

Incidence varies depending on the institution, patient population, allograph types, and immunosuppression regimes.

Etiology/Histopathology

Clinical settings causing immune dysfunctions, such as viral Epstein-Barr virus (EBV) infection, human viral immunodeficiency, autoimmune disease, and posttransplantation, can cause clonal B- and T-cell lymphoid proliferations, effacing and altering the normal histology architecture and causing symptoms and mass lesions.

Clinical Presentation

  • Fatigue

  • Pain

  • Mass lesions

  • Ulcers

  • Headache

  • Neurologic symptoms

  • Gastrointestinal symptoms

  • Dermatologic lesions

  • Organomegaly: enlarged lymph nodes, spleen, liver

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