This chapter includes an accompanying lecture presentation that has been prepared by the authors: Video 114.1 . Key Concepts Main complications in deep brain stimulation (DBS) surgery are intracerebral hemorrhage (the most feared complication owing to its consequences, but very…
Key Concepts Deep brain stimulation (DBS) consisting of high-frequency pulsatile stimulation to target structures (e.g., thalamus, subthalamic nucleus, globus pallidus internus) is a well-established surgical therapy for many neurological disorders, although the mechanism(s) of action underlying its therapeutic efficacy remains…
Acknowledgments R.L. Alterman wishes to thank Donald Weisz, PhD, for his assistance with the production of Figure 112.3 , for his friendship, and for his passionate commitment to patient care. This chapter includes an accompanying lecture presentation that has been…
This chapter includes an accompanying lecture presentation that has been prepared by the authors: Video 111.1. Key Concepts Deep brain stimulation (DBS) is the dominant surgical intervention for Parkinson disease (PD) because of its reversibility, adjustability, and applicability for bilateral…
Key Concepts Radiofrequency ablation, particularly pallidotomy, thalamotomy, and subthalamotomy, has been an effective surgical option for symptomatic relief of Parkinson disease for over 80 years. Ablation is particularly useful in patients for whom implanted hardware is contraindicated (e.g., infection risk,…
This chapter includes an accompanying lecture presentation that has been prepared by the authors: Video 109.1 . Key Concepts Tremor is probably the most common indication for surgery in patients with essential tremor (ET), symptoms of Parkinson disease, (PD) or…
This chapter includes an accompanying lecture presentation that has been prepared by the authors: Video 108.1 . Key Concepts Neuroimaging is a key component of safe and effective stereotactic intervention. Dedicated structural MRI sequences enable visualization of commonly used anatomic…
Acknowledgments This work was supported by grants from NIH (NS075321, NS41509, NS103957, NS075527, NCATS U54TR001456 & Office of Rare Disease Research), American Academy of Neurology & American Brain Foundation Clinical Research Training Fellowship, the Barnes Jewish Hospital Foundation (Elliot Stein…
This chapter includes an accompanying lecture presentation that has been prepared by the authors: Video 106.1 . Key Concepts The most important determinant for obtaining the best outcomes after deep brain stimulation (DBS) surgery is careful patient selection. The US…
Acknowledgments We would like to acknowledge the support of the National Parkinson Foundation via a Center of Excellence award, the McKnight Brain Institute (Gainesville, FL), the University of Florida, Shands Hospital (Gainesville, FL), and the Eric and Jennifer Scott Fund…