Practical Hepatic Pathology: A Diagnostic Approach

Vascular Disorders of the Liver

Abbreviations DIC disseminated intravascular coagulopathy EHPVO extrahepatic portal vein obstruction GSTM1 glutathione S-transferase M1 gene HELLP hemolysis, elevated liver enzymes and low platelets MRI magnetic resonance imaging NRH nodular regenerative hyperplasia SAAG serum-ascites albumin gradient VEGF vascular endothelial growth factor…

Intrahepatic Cholestasis

Molecular Physiology of Bile Formation and Secretion Marwan Ghabril, MD Bile is ubiquitous to almost all known vertebrate species. It is a complex aqueous but lipid rich solution composed of water, electrolytes, and a number of organic molecules including bile acids,…

Loss of Intrahepatic Bile Ducts

Abbreviations GSC Glucksberg-Seattle criteria GVHD graft-versus-host disease HCT hemopoietic cell transplantation HSCT hemopoietic stem cell transplantation IBMTR International Bone Marrow Transplant Registry K a a Although the prefix CK is widely used in surgical pathology to designate human cytokeratins, consensus…

Primary Sclerosing Cholangitis

Abbreviations AIDS acquired immunodeficiency syndrome AIH autoimmune hepatitis ALP alkaline phosphatase ALT alanine aminotransferase AMA antimitochondrial antibody AST aspartate aminotransferase ERCP endoscopic retrograde cholangiopancreatography GGT gamma-glutamyl transferase HLA human leukocyte antigen IBD inflammatory bowel disease IgG immunoglobulin G IgM immunoglobulin…

Primary Biliary Cholangitis

Abbreviations AIH autoimmune hepatitis ALP alkaline phosphatase ALT alanine aminotransferase AMA antimitochondrial antibody ANA antinuclear antibody AST aspartate aminotransferase K a a Although the prefix CK is widely used in surgical pathology to designate human cytokeratins, consensus nomenclature recommends the…

Fibrocystic Liver Diseases

Abbreviations ADPKD autosomal dominant polycystic kidney disease ADPLD autosomal dominant polycystic liver disease ARPKD autosomal recessive polycystic kidney disease CD Caroli disease CHF congenital hepatic fibrosis K a a Although the prefix CK is widely used in surgical pathology to…

Alcohol-Induced Liver Disease

Abbreviations AHHS alcoholic hepatitis histological score ALD alcoholic liver disease ALT alanine aminotransferase AASLD american association for the study of liver diseases AST aspartate aminotransferase GGT gamma glutamyl transpeptidase GH genetic hemochromatosis K keratin HCC hepatocellular carcinoma MCV mean corpuscular…

Liver Injury Due to Drugs and Herbal Agents

Abbreviations ALT alanine aminotransferase AST aspartate aminotransferase CDER Center for Drug Evaluation and Research CDS clinical diagnostic scale DILIN Drug-Induced Liver Injury Network DRESS drug reaction with eosinophilia and systemic symptoms FDA United States Food and Drug Administration HLA human…

Metabolism of Drugs and Xenobiotics

Abbreviations ABC adenosine triphosphate (ATP)–binding cassette ATP adenosine triphosphate AUC area under curve C max maximum plasma concentration CYP cytochrome P450 enzymes DILI drug-induced liver injury GST glutathione transferase NAT N -acetyltransferase SLC solute carrier SLT Shiga-like toxin SNP single-nucleotide…