Spectrum of fatty liver disease Thomas Addison, known for his description of the eponymous disease, was the first to use the term ‘fatty liver’ in the English medical literature in 1836, most likely referring to alcohol-related liver disease (ALD). Three…
CHAPTER CONTENTS Iron metabolism and homeostasis 295 Iron absorption and transport 295 Regulation of iron homeostasis 296 Hereditary iron overload 299 Hereditary haemochromatosis 299 Ferroportin disease 306 Hereditary hyperferritinaemia 307 Atransferrinaemia/hypotransferrinaemia 307 Acaeruloplasminaemia 308 Miscellaneous iron overload 308 Neonatal haemochromatosis…
. Developmental and inherited disorders affecting the liver typically present in childhood but may affect individuals of any age. The effect of inherited metabolic disorders on the liver may be considered primary , caused by the accumulation of a metabolite…
CHAPTER CONTENTS Liver biopsy 96 Evolving role 96 Different types 97 Limitations of and requirements forinterpretation 99 Competitors and alternatives to liver biopsy 100 Routine handling, fixation and staining of liver specimens 103 Handling and fixation 103 Staining 104 Immunohistochemistry…
. The practice of hepatopathology requires a clear understanding of liver anatomy and physiology, as a prelude to understanding the expression of pathological processes in the liver. As an anatomical entity, the liver is deceptively simple. It is large, representing…